MATTEO IANNACONE

Matteo Iannacone

EDUCATION

  • 2011: Ph.D. in Molecular Medicine, Section of Basic and Applied Immunology, Universita’ Vita-Salute San Raffaele, Milan, Italy

  • 2007: Board Certification in Internal Medicine (summa cum laude), Università Vita-Salute San Raffaele, Milan, Italy

  • 2001: M.D. degree summa cum laude, University of Milan, Italy

POSITIONS AND TRAINING

  • 2015 – present: Head, Dynamics of Immune Responses, San Raffaele Scientific Institute, Milan, Italy

  • 2010 – 2015: Group Leader, Dynamics of Immune Responses, San Raffaele Scientific Institute, Milan, Italy

  • 2007 – 2010: Postdoctoral Fellow, Laboratory of Prof. Ulrich von Andrian, Harvard Medical School, Boston, MA

  • 2003 – 2007: Resident in Internal Medicine, San Raffaele Scientific Institute, Milan, Italy

  • 2001 – 2003: Postdoctoral Fellow, Laboratory of Prof. L.G. Guidotti and Prof. F.V. Chisari, The Scripps Research Institute, La Jolla, CA

HONORS AND AWARDS

  • 2017: Chiara D’Onofrio Award
  • 2016: European Research Council (ERC) Consolidator Grant

  • 2016: EMBO Young Investigator Award

  • 2015: European Association for the Study of the Liver (EASL) Young Investigator Award
  • 2011: European Research Council (ERC) Starting Grant

  • 2010: Armenise-Harvard Foundation Career Development Award
  • 2008: Armenise-Harvard Foundation Postdoctoral Fellowship

PROFESSIONAL ACTIVITIES

  • Journal Reviewer: Nature, Science, Nature Medicine, Immunity, Nature Immunology, Journal of Clinical Investigation, Science Translational Medicine, Science Immunology, Proceedings of the National Academy of Sciences, Cell Host & Microbe, Trends in Immunology, Cell Reports, Nature Communications, eLife, PLoS Pathogens, Hepatology, Journal of Hepatology, Gastroenterology, Journal of Immunology, Journal of Virology

  • Grant Reviewer: European Research Council (ERC), UK Medical Research Council (MRC), European Molecular Biology Organization (EMBO), Marie Curie Individual Fellowships, Institut National de la Sante et de la Recherche Medicale (INSERM, Panel Member for the ATIP-AVENIR Program), Centre National de la Recherche Scientifique (CNRS), French National Research Agency (ANR), Israel Science Foundation, Swiss National Science Foundation, Austrian Science Fund (FWF), Swiss Cancer League, Agency for Science, Technology & Research (A*STAR) in Singapore, Singapore National Medical Research Council (Panel Member 2018-2020), Canadian Institutes of Health Research.

  • Editorial Board: Frontiers in Immunology (Associate Editor for Immunological Memory and Viral Immunology), Current Opinion in Virology (Invited Section Editor)

  • Conference Organization: 1st International Workshop “Imaging the Immune System”, Milan, Italy (2014), International Workshop “Viral Immunity”, Milan (2016), 2nd International Workshop “Imaging the Immune System”, Rehovot, Israel (2016), 1st EMBO Sectoral Meeting on Immunology, Bergamo, Italy (2017), MACS day “T cells”, Milan, Italy (2017), 3rd International Workshop “Imaging the Immune System”, Paris, France (2018), 2nd EMBO Sectoral Meeting on Immunology, Lisbon, Portugal (2018), 1st EMBO Workshop “Pathogen Immunity and Signaling”, Oxford, UK (2019), 3rd EMBO Sectoral Meeting on Immunology, Cambridge, UK (2019), 20th Germinal Center Conference, Rehovot, Israel (2020).

MAJOR ADMINISTRATIVE AND INSTITUTIONAL RESPONSIBILITIES

  • 2014 – present: Director, Intravital Imaging Facility, San Raffaele Scientific Institute, Milan, Italy

  • 2014 – present: Immunology Seminar Series Organizing Committee, San Raffaele Scientific Institute, Milan, Italy

  • 2015 – present: External Seminar Committee, San Raffaele Scientific Institute, Milan, Italy

  • 2017 – present: Scientific Board, PhD program in Molecular Medicine, Vita-Salute San Raffaele University, Milan, Italy

TEACHING EXPERIENCE

  • 2012 – present: Adjunct Professor of Pathology and Immunology, Vita-Salute San Raffaele University, Milan, Italy

CONSULTANTSHIPS

  • Gilead Sciences, Foster City, CA – Selecta Biosciences, Cambridge, MA

PATENTS

  • Immunonanotherapeutics that Provide IgG Humoral Response without T-Cell Antigen, United States Patent 8,906,381

  • Targeting of Antigen Presenting Cells with Immunonanotherapeutics, United States Patents 9,308,280

  • Adjuvant Incorporation in Immunonanotherapeutics, United States Patent 9,439,859

  • Nicotine Immunonanotherapeutics, United States Patent 8,932,595

  • Vaccine Nanotechnology, United States Patent 9,539,210

  • Vaccines Comprising Bisphosphonates and Methods of Use Thereof, United States Patent Application 20130309270

  • Inhibitors of Hepatitis B Virus, European Patent 18184456.4 – 1116

  • Cyclic Inhibitors of Hepatitis B Virus, European Patent 18184450.7 – 1116

  • Tricyclic Inhibitors of Hepatitis B Virus, European Patent 18188409.9 – 1116

CURRENT FUNDING

  • European Research Council – Consolidator Grant (725038)

    FUNCTIONAL BIOLOGY OF HEPATIC CD8+ T CELLS
    €2,390,000
    Jul 2017 – Jun 2022
    Iannacone (Principal Investigator)

  • AIRC (Italian Association for Cancer Research) – Individual Grant MFAG (15350)

    THE ROLE OF ANTIGENIC STIMULATION IN THE PATHOGENESIS OF CHRONIC LYMPHOCYTIC LEUKEMIA
    €225,000
    Mar 2015 – Feb 2018
    Iannacone (Principal Investigator)

  • Italian Ministry of Health – Giovani Ricercatori (GR-2011-02347925)

    DISSECTING HBV PATHOGENESIS THROUGH THE USE OF INTRAVITAL MICROSCOPY
    €342,000
    Nov 2014 – Nov 2017
    Iannacone (Principal Investigator)

  • Fondazione Regionale per la Ricerca Biomedica (2015-0010)

    SINGLE-CELL ANALYSES OF LYMPHOCYTES THAT INFILTRATE AUTOIMMUNITY SITES: DISSECTING IMMUNOLOGICAL MECHANISMS OF RHEUMATOID ARTHRITIS
    €630,000
    2017 – 2020
    Iannacone (Co-Principal Investigator)

  • Italian Ministry of Health – Ricerca Finalizzata (RF-2018-12365801)

    DETERMINANTS OF INTRAHEPATIC CD8+ T CELL PRIMING
    €450,000
    Nov 2019– Nov 2022
    Iannacone (Principal Investigator)

  • Funding from Gilead Sciences and GSK Vaccines

COMPLETED FUNDING

  • Armenise-Harvard Foundation – Career Development Award

    IN VIVO IMAGING OF ANTIVIRAL IMMUNE RESPONSES
    $1,000,000
    Nov 2010 – Oct 2015
    Iannacone (Principal Investigator)

  • AIRC (Italian Association for Cancer Research) – Program Project (9965)

    HARNESSING TUMOUR CELL/MICROENVIRONMENT CROSS TALK TO TREAT MATURE B-CELL TUMOURS
    €420,000
    Nov 2010 – Oct 2015
    Iannacone (Group Leader)

  • Armenise-Harvard Foundation – Senior Postdoctoral Fellowship

    ANTIVIRAL IMMUNE RESPONSES IN LYMPH NODES
    $180,000
    Apr 2008 – Apr 2010
    Iannacone (Principal Investigator)

  • AIRC (Italian Association for Cancer Research) – Individual Grant MFAG (15350)

    THE ROLE OF ANTIGENIC STIMULATION IN THE PATHOGENESIS OF CHRONIC LYMPHOCYTIC LEUKEMIA
    €225,000
    Jan 2015 – Dec 2017
    Iannacone (Principal Investigator)

  • Funding from Novartis Vaccines and Selecta Biosciences

  • European Research Council – Starting Grant (281648)

    IN VIVO DYNAMICS OF ANTIBODY RESPONSES TO LYMPH-BORNE VIRUSES
    €1,934,200
    Mar 2012 – Jun 2017
    Iannacone (Principal Investigator)

SELECTED INVITED LECTURES

2019, Institut Curie, Paris, France (hosts: Ana-Maria Lennon-Dumenil, Nicolas Manel)
2019, The Convergence of Hematology and Immunology (CHI), Tianjin, China
2019, International Congress of Immunology, Beijing
2019, Joint German-Italian Immunological Society meeting, Munich
2019, Swiss Society of Allergology and Immunology meeting, Lugano, Switzerland
2019, EMBO Young Scientist Forum, Prague, Czech Republic
2019, Immune Cell Responses Unfolded by Single Cell Technologies, Karolinska Institute
2019, TRON, Mainz, Germany (host: Ugur Sahin)
2019, EASL International Liver Congress, Vienna, Austria
2019, EMBO Gold Medalists Meeting, Singapore
2019, Department of Pathology, UCSF (host: Max Krummel)
2019, Gilead Sciences, Foster City, CA (host: Sarah Gilmore)
2019, Stanford University, CA (host: Maria Grazia Roncarolo)
2019, IRBM Science Park, Roma (host: Carlo Toniatti)
2019, Harald von Boehmer Midwinter Conference, Seefeld, Austria
2018, Virology Meeting, Catalan Society of Biology, Barcelona, Spain
2018, Cumming School of Medicine, University of Calgary, Canada (host: Paul Kubes)
2018, Translational Approaches to Inflammatory Liver Injury and Repair, Banff, Canada
2018, World Congress on Microcirculation, Vancouver, Canada
2018, 5th European Congress of Immunology, Amsterdam
2018, SIICA Advanced School in Immunology, Messina, Italy
2018, European Institute of Oncology, Milan, Italy (host: Luigi Nezi)
2018, Oxford University, UK (host: Jan Rehwinkel)
2018, Cambridge University, UK (host: Milka Sarris)
2018, 44th Portuguese Society for Immunology Meeting, Lisbon, Portugal
2018, Gordon Research Conference on Immunochemistry and Immunobiology, VT
2018, Gordon Research Conference on Chemotactic Cytokines, Newry, ME
2018, TRR179 Symposium on Viral hepatitis and strategies of persistence, Heidelberg
2018, DKFZ, Heidelberg (host: Hellmut Augustin)
2018, 33rd Congress of the International Society for Advancement of Cytometry, Prague
2018, The Crick Institute, London, UK (host: Caetano Reis e Sousa)
2018, William Harvey Research Institute, London UK (host: Sussan Nourshargh)
2018, University of Bern, Switzerland (host: Jens Stein)
2018, University of Perugia, Italy (host: Francesca Fallarino)
2018, Falk Foundation Workshop ‘Liver-Gut-Microbiome Interactions’, Hamburg, Germany
2018, 27th Cytomeet (Keynote Lecture), Bern, Switzerland
2018, Institute for Immunology, Munich, Germany (host: Thomas Brocker)
2017, ETH, Zurich, Switzerland (host: Annette Oxenius)
2017, VIB-KU Leuven Center for Cancer Biology, Leuven, Belgium (host: Max Mazzone)
2017, deLIVER – Technology in Hepatology, Duesseldorf, Germany (Keynote lecture)
2017, NIAID, NIH, Bethesda, MD (hosts: Ron Germain and Jon Yewdell)
2017, Armenise lecture at the Italian Society for Biophysics and Molecular Biology (SIBBM) meeting, Milan, Italy
2017, British Society of Immunology Leukocyte Migration Affinity Group, Leeds, UK
2017, EMBO Symposium on Antigen Presentation, Salamanca, Spain
2017, XI Meeting of the Italian Immunological Society (SIICA), Bari, Italy
2017, CRC/SFB 900 Symposium in Hannover, Germany
2017, Centre d’Immunologie de Marseille-Luminy, France (host: Toby Lawrence)
2017, Laboratory of Molecular and Cellular Biology (LMCB), University College London, UK (host: Sophie Acton)
2017, Gotheborg University, Sweden (host: Susanna Cardell)
2016, Perspective in Vascular Biology (SFB 834), Frankfurt, Germany
2016, University of Bern, Switzerland (host: Jens Stein)
2016, Gordon Research Conference “Immunochemistry and Immunobiology”, Il Ciocco, Italy
2016, The Francis Crick Institute, London, UK (host: Caetano Reis e Sousa)
2016, Symposium on Immunity and Inflammation, CNIC, Madrid, Spain
2016, Pasteur Institute, Paris, France (host: Claude Leclerc)
2016, 8th International Singapore Symposium of Immunology, Singapore
2016, EMBO Young Investigator Meeting, Heidelberg, Germany
2016, Roche Glycart AG, Schlieren, Switzerland (host: Mario Perro)
2016, TIGEM, Naples, Italy (host: Carmine Settembre)
2016, University of Turin (host: Emilio Hirsch)
2016, Immunology Day, La Sapienza University, Rome, Italy
2015, GSK Vaccines, Siena, Italy (host: Ugo D’Oro)
2015, Trafficking of immune cells in inflammation, development and disease (SFB 914), Italy
2015, TRON, Mainz, Germany (hosts: Ugur Sahin)
2015, Karolinska Institute, Stockholm, Sweden (host: Eduardo Villablanca)
2015, University of Oxford, UK (host: Oliver Bannard)
2015, Cancer Research UK, London, UK (host: Facundo Batista)
2015, University College London, UK (host: Mala Maini)
2015, Istituto Nazionale Genetica Molecolare, Milano, Italy (host: Jens Geginat)
2015, University of Bern, Switzerland (host: Philippe Krebs)
2015, 1st European Chemokine and Cell Migration Conference, Villars-sur-Ollon, Switzerland
2015, European Society of Clinical Investigation Meeting, Cluj, Romania
2015, EASL International Liver Congress, Vienna, Austria
2015, University of Milan, Italy (host: Graziella Messina)
2015, Annual Meeting of the Swiss Society for Allergology and Immunology, Basel
2014, University of Freiburg, Germany (host: Robert Thimme)
2014, University of Essen, Germany (host: Karl Lang)
2014, Karolinska Institute, Stockholm, Sweden (host: Matti Sallberg)
2014, 3rd Conference on Translational Medicine on Pathogenesis and Therapy of Immune-mediated Diseases, Milan, Italy
2014, Vaccine and Gene Therapy Institute, Oregon Health & Science University, Portland, Oregon (host: Klaus Frueh)
2014, Technical University in Munich, Germany (host: Percy Knolle)
2014, University of Calgary, Alberta, Canada (host: Paul Kubes)
2014, Vaccine Technology V, Playa Del Carmen, Mexico
2014, Symposium of the Research Unit 1202 “Determinants of elimination and persistence of hepatitis viruses”, Heidelberg, Germany
2014, 7th International Workshop “Bridging the gap”, Medical University of Vienna, Austria
2013, Institut Pasteur of Shanghai – Chinese Academy of Sciences, Shanghai, China (host: Jin Zhong)
2013, Spanish National Centre for Biotechnology (CNB), Madrid, Spain (host: Pablo Gastaminza)
2013, 15th International Congress of Immunology, Milan, Italy
2013, 23rd Conference of the Asian Pacific Association for the Study of the Liver (APASL), Singapore
2013, Keystone Symposium on Myeloid cells: Regulation and Inflammation, Keystone, Colorado, USA
2012, 43rd International Conference, Pio Manzu’ International Research Center, Rimini, Italy
2012, Novartis Vaccines and Diagnostic Research Center, Siena, Italy (host: Ennio De Gregorio)
2012, CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria (host: Giulio Superti-Furga)
2012, Immunobiology of Microbial Host Interactions, 14th Annual Armenise-Harvard Foundation Symposium, Borgo San Luigi (Siena), Italy
2011, Ph.D. Student Retreat of the Institute for Research in Biomedicine, Bellinzona, Switzerland
2011, Department of Pathology and Immunology and W.H.O. Collaborating Centre for Vaccine Immunology, University of Geneva, Switzerland (host: Daniel Pinschewer)
2011, Trafficking of immune cells in inflammation, development and disease, Villa Vigoni (Menaggio), Italy
2011, Opening Plenary Symposium, Joint Meeting of the German (DGfI) and Italian (SIICA) Immunological Societies, Riccione, Italy
2011, The Weatherall Institute for Molecular Medicine, University of Oxford, UK (host: Enzo Cerundolo)
2011, Major Symposium on Innate Immunity, 98th Annual Meeting of the American Association of Immunologists, San Francisco, USA
2011, Institut Curie, Paris, France (host: Ana Maria Lennon-Dumenil)
2011, ICGEB Trieste, Italy (host: Federica Benvenuti)
2010, 11th International Symposium on Dendritic Cells in Fundamental and Clinical Immunology, Lugano, Switzerland
2010, University of Toledo, OH, USA (host: Isabel Novella)
2010, 4th International Symposium, Immunology Frontier Research Center, Osaka University, Japan
2010, Istituto Clinico Humanitas, Milan, Italy (host: Anna Villa)
2009, Immunochile – 9th Latin American Congress of Immunology, Vina del Mar, Chile